The guests selected to bat first however posted a modest general of 182 for 9 and, propelled by way of a part century from Andrew Balbirnie, Eire reached their goal of 183 with six overs to spare.
The edges will meet once more on Friday to make a decision the sequence.
Afghanistan got here into the tournament having gained the T20 sequence between the groups 2-Zero remaining week and after easing to a 29-run win within the first ODI on Monday.
Then again, they have been lowered to 16-Four within 10 overs.
Captain Asghar Afghan steadied the send, but if he used to be brilliantly run out for 39 by way of Paul Stirling, Afghanistan have been 100-7.
Najibullah Zadran most sensible scored with 42 to no less than give the vacationers hope they usually made Eire paintings for victory.
Stirling and Balbirnie were given Eire off to a flyer at 69-1 earlier than 3 fast wickets put the sport again within the steadiness.
Balbirnie additionally made a 50 within the opening tournament of the sequence and were given to 60 earlier than being pushed aside by way of the spectacular Rashid Khan.
Some other two wickets fell in fast succession to arrange a grandstand end, however Simi Singh’s 36 no longer out noticed Eire over the road to stage up the sequence.